KMID : 1007520230320091269
|
|
Food Science and Biotechnology 2023 Volume.32 No. 9 p.1269 ~ p.1279
|
|
Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil
|
|
Lee Tae-Kyung
Hur Gi-Hyun Choi Jeong-Yoon Ban Choong-Jin Yang Ji-Hye Yang Hee Jung Han Yoon Park Lee Ki-Won Kim Jong-Hun
|
|
Abstract
|
|
|
The effect of nanoemulsions on the stability and bioavailability of sulforaphene (SFEN) in radish seed extract (RSE) was investigated. Four types of oil were used as lipid ingredients of the nanoemulsions: soybean, high oleic acid sunflower, coconut, and hydrogenated palm oils. SFEN in RSE nanoemulsions showed greater stability to temperature, acid, and alkaline conditions than SFEN in RSE suspended in water (RSE-S). Particularly under alkaline conditions, the half-life of SFEN in the nanoemulsion with high oleic sunflower oil (RSE-HOSO) was 8?times longer than that of RSE-S. Furthermore, in the pharmacokinetics study, it was observed that AUC0?8 increased and oral clearance (CL/F) decreased significantly in rats orally administered RSE-HOSO compared with RSE-S (p?0.05). This study indicates that the type of oil used in nanoemulsions affects the stability and bioavailability of SFEN in RSE. These results may provide a guideline for the development of functional foods containing RSE.
|
|
KEYWORD
|
|
Radish seeds, Nanoemulsion, Vegetable oils, Storage stability, Pharmacokinetics
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|